Molecular Tools to Generate Reactive Oxygen Species in Biological Systems
نویسندگان
چکیده
منابع مشابه
O 22: Reactive Oxygen Species and Epilepsy
Seizure activity has been proposed to result in the generation of reactive oxygen species (ROS), which then contribute to seizure-induced neuronal damage and eventually cell death. Although the mechanisms of seizure-induced ROS generation are unclear, mitochondria and cellular calcium overload have been proposed to have a crucial role. We aim to determine the sources of seizure-induced ROS and ...
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Tolerance to lipopolysaccharide (LPS) occurs when animals or cells exposed to LPS become hyporesponsive to a subsequent challenge with LPS. This mechanism is believed to be involved in the down-regulation of cellular responses observed in septic patients. The aim of this investigation was to evaluate LPS-induced monocyte tolerance of healthy volunteers using whole blood. The detection of intrac...
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The production of reactive oxygen species (ROS), via consumption of oxygen in a so-called oxidative burst, is one of the earliest cellular responses following successful pathogen recognition. Apoplastic generation of superoxide (O2 ), or its dismutation product hydrogen peroxide (H2O2), has been documented following recognition of a variety of pathogens (Doke, 1983; Auh and Murphy, 1995; Grant ...
متن کاملThe Effect of FK506 to Generate Reactive Oxygen Species on T Lymphocyte Death
Purpose: Tacrolimus (FK506) has been widely used as an immunosuppressant in organ transplanted recipients to suppress organ rejection phenomenon. We investigated the role of oxidative stress and heme oxygense-1 by FK506 on human Jurkat T cells. Methods: The cells viability was examined by DAPI stain, enzyme activity of caspase family proteins, and western blotting for Baks, PUMA, iNOS, HO-1. Ce...
متن کاملMolecular and biochemical mechanisms in teratogenesis involving reactive oxygen species.
Developmental pathologies may result from endogenous or xenobiotic-enhanced formation of reactive oxygen species (ROS), which oxidatively damage cellular macromolecules and/or alter signal transduction. This minireview focuses upon several model drugs (phenytoin, thalidomide, methamphetamine), environmental chemicals (benzo[a]pyrene) and gamma irradiation to examine this hypothesis in vivo and ...
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ژورنال
عنوان ژورنال: Bioconjugate Chemistry
سال: 2019
ISSN: 1043-1802,1520-4812
DOI: 10.1021/acs.bioconjchem.9b00191